Representation of Natural Stimuli in the Rodent Main Olfactory Bulb

Lin, D. Y., Shea, S. D., Katz, L. C. (2006) Representation of Natural Stimuli in the Rodent Main Olfactory Bulb. Neuron, 50 (6). pp. 937-949. ISSN 08966273 (ISSN)

DOI: 10.1016/j.neuron.2006.03.021


Natural odorants are complex mixtures of diverse chemical compounds. Monomolecular odorants are represented in the main olfactory bulb by distinct spatial patterns of activated glomeruli. However, it remains unclear how individual compounds contribute to population representations of natural stimuli, which appear to be unexpectedly sparse. We combined gas chromatography and intrinsic signal imaging to visualize glomerular responses to natural stimuli and their fractionated components. While whole stimuli activated up to 20 visible glomeruli, each fractionated component activated only one or few glomeruli, and most glomeruli were activated by only one component. Thus, responses to complex mixtures reflected activation by multiple components, with each contributing only a small part of the overall representation. We conclude that the population response to a complex stimulus is largely the sum of the responses to its individual components, and activation of an individual glomerulus independently signals the presence of a specific component. © 2006 Elsevier Inc. All rights reserved.

Item Type: Paper
Uncontrolled Keywords: SYSNEURO animal experiment article controlled study female fractionation gas chromatography mouse neuroimaging nonhuman olfactory bulb priority journal signal transduction smelling Animals Brain Mapping Chromatography, Gas Foxes Lynx Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Odors Rats Sensitivity and Specificity Smell
Subjects: organism description > animal > mammal > rodent > mouse
organism description > animal behavior > odor recognition
organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb
CSHL Authors:
Communities: CSHL labs > Shea lab
Depositing User: Leigh Johnson
Date: 2006
Date Deposited: 26 Mar 2012 18:12
Last Modified: 10 Feb 2017 22:03
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