Stillman, B. (December 1996) Cell cycle control of DNA replication. Science, 274 (5293). pp. 1659-64. ISSN 0036-8075 (Print)
Abstract
The initiation of DNA replication in eukaryotic cells is a highly regulated process that leads to the duplication of the genetic information for the next cell generation. This requires the ordered assembly of many proteins at the origins of DNA replication to form a competent, pre-replicative chromosomal state. In addition to this competent complex, at least two cell cycle regulated protein kinase pathways are required to affect a transition to a post-replicative chromosomal state. Protein kinases required to establish mitosis prevent re-replication of the DNA. As cells exit mitosis, the cell cycle is reset, allowing the establishment of a new, competent replication state.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Cell Cycle Cell Cycle Proteins metabolism Chromosomes metabolism Cyclin-Dependent Kinases metabolism Cyclins metabolism DNA Replication Fungal Proteins metabolism Mitosis Protein Kinases metabolism Protein-Serine-Threonine Kinases Replication Origin S Phase Saccharomyces cerevisiae cytology metabolism Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication |
| CSHL Authors: | |
| Communities: | CSHL labs > Stillman lab |
| Highlight: | Stillman, Bruce W. |
| Depositing User: | CSHL Librarian |
| Date: | 6 December 1996 |
| Date Deposited: | 29 Feb 2012 16:53 |
| Last Modified: | 20 Jun 2017 19:36 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/25079 |
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