Ibarra, I., Erlich, Y., Muthuswamy, S. K., Sachidanandam, R., Hannon, Gregory J. (December 2007) A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev, 21 (24). pp. 3238-43. ISSN 0890-9369 (Print)
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Abstract
microRNA (miRNA) expression profiles are often characteristic of specific cell types. The mouse mammary epithelial cell line, Comma-Dbeta, contains a population of self-renewing progenitor cells that can reconstitute the mammary gland. We purified this population and determined its miRNA signature. Several microRNAs, including miR-205 and miR-22, are highly expressed in mammary progenitor cells, while others, including let-7 and miR-93, are depleted. Let-7 sensors can be used to prospectively enrich self-renewing populations, and enforced let-7 expression induces loss of self-renewing cells from mixed cultures.
| Item Type: | Paper |
|---|---|
| Additional Information: | 0890-9369 (Print) |
| Uncontrolled Keywords: | RNAi microRNA stem cell |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA organs, tissues, organelles, cell types and functions > tissues types and functions > mammary gland organism description > animal > mammal > rodent > mouse therapies > stem cells |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab CSHL labs > Muthuswamy lab CSHL labs > Sachidanandam lab School of Biological Sciences > Publications |
| Depositing User: | CSHL Librarian |
| Date: | 15 December 2007 |
| Date Deposited: | 14 Nov 2011 19:06 |
| Last Modified: | 22 Sep 2014 15:03 |
| PMCID: | PMC2113025 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/23046 |
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