Control of translation and mRNA degradation by miRNAs and siRNAs

Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., Parker, R. (2006) Control of translation and mRNA degradation by miRNAs and siRNAs. Genes and Development, 20 (5). pp. 515-524. ISSN 08909369

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Abstract

The control of translation and mRNA degradation is an important part of the regulation of gene expression. It is now clear that small RNA molecules are common and effective modulators of gene expression in many eukaryotic cells. These small RNAs that control gene expression can be either endogenous or exogenous micro RNAs (miRNAs) and short interfering RNAs (siRNAs) and can affect mRNA degradation and translation, as well as chromatin structure, thereby having impacts on transcription rates. In this review, we discuss possible mechanisms by which miRNAs control translation and mRNA degradation. An emerging theme is that miRNAs, and siRNAs to some extent, target mRNAs to the general eukaryotic machinery for mRNA degradation and translation control. © 2006 by Cold Spring Harbor Laboratory Press.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mRNA dynamics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > sRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > siRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > translation
CSHL Authors:	Hannon, Gregory J. Liu, Jidong
Communities:	CSHL labs > Hannon lab
Depositing User:	CSHL Librarian
Date:	2006
Date Deposited:	08 Dec 2011 20:33
Last Modified:	01 Dec 2016 17:20
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/22920

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