Osten, P., Stern-Bach, Y. (June 2006) Learning from stargazin: the mouse, the phenotype and the unexpected. Current Opinion in Neurobiology, 16 (3). pp. 275-80. ISSN 0959-4388
Abstract
The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC), and a deficit in its role as auxiliary VDCC subunit was proposed to underlie the epileptic phenotype of the mouse; yet, a conclusive demonstration of stargazin function in VDCC regulation is still lacking. In contrast, stargazin and its three closely related isoforms gamma-3, gamma-4 and gamma-8 were shown to function as auxiliary subunits for a very different ion channel - the AMPA-type glutamate receptor - prominently regulating early intracellular transport, synaptic targeting and anchoring, and ion channel functions of this major excitatory receptor in the brain.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Brain metabolism physiopathology Calcium Channels genetics metabolism Mice Mice Neurologic Mutants Phenotype Protein Isoforms genetics metabolism Protein Subunits genetics metabolism Protein Transport/genetics Receptors, AMPA/genetics/*metabolism Synapses/genetics/*metabolism Synaptic Transmission/*genetics |
| Subjects: | organism description > animal behavior organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > calcium channel organism description > animal > mammal > rodent > mouse |
| CSHL Authors: | |
| Communities: | CSHL labs > Osten lab |
| Depositing User: | CSHL Librarian |
| Date: | 16 June 2006 |
| Date Deposited: | 09 Dec 2011 18:04 |
| Last Modified: | 08 Apr 2013 15:09 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22875 |
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