Hirano, T. (February 2005) Cell biology - Holding sisters for repair. Nature, 433 (7025). pp. 467-468. ISSN 0028-0836
Abstract
Before a cell divides, it must replicate its DNA, producing two identical copies of each chromosome, known as sister chromatids. When one of the sister chromatids suffers a break that affects both of its DNA strands, it is mended by 'homologous recombination'. In this process, information on the undamaged sister is used as a template for repair. This mechanism is essential for cell survival and genome stability. But how can the repair machinery find the proper template in the crowded environment of the cell nucleus? Writing in Molecular Cell, Ünal et al.1 and Ström et al.2 provide compelling evidence that a protein complex called cohesin has a crucial role.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Double Strand break DNA damage Chromatid cohesion SMC1 recruitment pathway |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromatid |
| CSHL Authors: | |
| Communities: | CSHL labs > Hirano lab |
| Depositing User: | CSHL Librarian |
| Date: | February 2005 |
| Date Deposited: | 12 Jan 2012 19:37 |
| Last Modified: | 07 May 2018 15:18 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22595 |
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