TARGETing "when" and "where"

Wang, Y., Zhong, Y. (February 2004) TARGETing "when" and "where". Sci STKE, 2004 (220). pe5. ISSN 1525-8882 (Electronic)

DOI: 10.1126/stke.2202004pe5


In Drosophila, the cyclic adenosine monophosphate (cAMP) pathway has been shown to be crucial for learning and memory, but whether this represents a developmental or a specific effect has not been resolved. Research with a new targeting system that allows both spatial and temporal control of gene expression shows that expression of rutabaga-encoded adenylyl cyclase, a component of the cAMP signaling pathway, in the mushroom bodies of adult flies is necessary and sufficient to rescue the learning defect of rutabaga mutant. This demonstrates an acute role for Rutabaga in learning and memory.

Item Type: Paper
Uncontrolled Keywords: Animals Brain Chemistry genetics Gene Expression Regulation genetics Learning physiology Memory physiology Signal Transduction genetics
Subjects: organism description > animal behavior > learning
organism description > animal behavior > memory
CSHL Authors:
Depositing User: CSHL Librarian
Date: 17 February 2004
Date Deposited: 17 Jan 2012 17:25
Last Modified: 17 Jan 2012 17:25

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