p63 is the molecular switch for initiation of an epithelial stratification program

Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., Roop, D. R. (January 2004) p63 is the molecular switch for initiation of an epithelial stratification program. Genes & Development, 18 (2). pp. 126-131. ISSN 0890-9369

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URL: https://www.ncbi.nlm.nih.gov/pubmed/14729569
DOI: 10.1101/gad.1165104


Development of stratified epithelia, such as the epidermis, requires p63 expression. The p63 gene encodes isoforms that contain (TA) or lack (DeltaN) a transactivation domain. We demonstrate that TAp63 isoforms are the first to be expressed during embryogenesis and are required for initiation of epithelial stratification. In addition, TAp63 isoforms inhibit terminal differentiation, suggesting that TAp63 isoforms must be counterbalanced by DeltaNp63 isoforms to allow cells to respond to signals required for maturation of embryonic epidermis. Our data demonstrate that p63 plays a dual role: initiating epithelial stratification during development and maintaining proliferative potential of basal keratino-cytes in mature epidermis.

Item Type: Paper
Uncontrolled Keywords: p63 stratified epithelia molecular switch embryogenesis terminal differentiation proliferative potential TRANSGENIC MICE transgenic mice GENE-EXPRESSION gene expression P53 HOMOLOG p53 homolog IKK-ALPHa TKK-Alpha TKK-alpha KAPPA-B DIFFERENTIATION differentiation DELTA-NP63-ALPHA Delta_NP63-Alpha ACTIVATION Activation activation EPIDERMIS epidermis SKIN skin
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > embryogenesis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: CSHL Librarian
Date: January 2004
Date Deposited: 01 Feb 2012 18:06
Last Modified: 02 Feb 2017 20:04
PMCID: PMC324418
Related URLs:
URI: https://repository.cshl.edu/id/eprint/22415

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