Harrison, M., Li, J., Degenhardt, Y., Hoey, T., Powers, S. (August 2004) Wip1-deficient mice are resistant to common cancer genes. Trends in Molecular Medicine, 10 (8). pp. 359-361. ISSN 1471-4914
Abstract
PPM1D encodes WIP1, a serine-threonine phosphatase that had previously been shown to be the driver oncogene of a 17q23 amplicon that is present in similar to15% of human breast tumors. However, it is unknown whether it has any role in the remaining 85% of breast tumors. A recent study using Wip1-deficient mice revealed that blocking its function significantly impaired RAS and ERBB2-induced breast tumor formation, suggesting that the inhibition of Wip1 could be a broad-spectrum treatment for breast cancer. However, because of the structure of Wip1, the development of small molecule inhibitors is a significant challenge.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | COMPARATIVE GENOMIC HYBRIDIZATION comparative genomic hybridisation BREAST-CANCER breast cancer PHOSPHATASE phosphatase WIP1 AMPLIFICATION amplification RADIATION radiation TUMORS tumors PPM1D |
| Subjects: | diseases & disorders > cancer > cancer types > breast cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein phosphatase |
| CSHL Authors: | |
| Communities: | CSHL labs > Powers lab |
| Depositing User: | CSHL Librarian |
| Date: | August 2004 |
| Date Deposited: | 01 Feb 2012 18:16 |
| Last Modified: | 02 May 2013 20:12 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22383 |
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