Unlocking the potential of the human genome with RNA interference

Hannon, G. J., Rossi, J. J. (September 2004) Unlocking the potential of the human genome with RNA interference. Nature, 431 (7006). pp. 371-8. ISSN 1476-4687 (Electronic)

URL: https://www.ncbi.nlm.nih.gov/pubmed/15372045
DOI: 10.1038/nature02870


The discovery of RNA interference (RNAi) may well be one of the transforming events in biology in the past decade. RNAi can result in gene silencing or even in the expulsion of sequences from the genome. Harnessed as an experimental tool, RNAi has revolutionized approaches to decoding gene function. It also has the potential to be exploited therapeutically, and clinical trials to test this possibility are already being planned.

Item Type: Paper
Uncontrolled Keywords: Animals Drug Evaluation Preclinical/methods Gene Therapy methods Genome Human Genomics methods Humans RNA Interference RNA Small Interfering genetics metabolism
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi
CSHL Authors:
Communities: CSHL labs > Hannon lab
Depositing User: CSHL Librarian
Date: 16 September 2004
Date Deposited: 09 Feb 2012 15:31
Last Modified: 02 Dec 2016 19:57
Related URLs:
URI: https://repository.cshl.edu/id/eprint/22380

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