Notch signaling in Drosophila long-term memory formation

Ge, X. C., Hannan, F., Xie, Z. L., Feng, C. H., Tully, T., Zhou, H. M., Xie, Z. P., Zhong, Y. (July 2004) Notch signaling in Drosophila long-term memory formation. Proceedings of the National Academy of Sciences of the United States of America, 101 (27). pp. 10172-10176. ISSN 0027-8424

[thumbnail of Paper]
PDF (Paper)
Tully and Zhong PNAS 2004.pdf - Published Version

Download (338kB) | Preview
DOI: 10.1073/pnas.0403497101


Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, neither learning nor early memory were affected. Furthermore, induced overexpression of a wild-type (normal) N transgene specifically enhanced LTM formation. These experiments demonstrate that N signaling contributes to LTM formation in the Drosophila adult brain.

Item Type: Paper
Uncontrolled Keywords: ALZHEIMERS-DISEASE Alzheimer's disease BINDING PROTEIN protein binding CELL FATES cell fates MELANOGASTER Melanogaster COMPLEX Complex MICE SPECIFICATION specification SUPPRESSOR suppressor REPRESSION EXPRESSION
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior > olfactory
CSHL Authors:
Communities: CSHL labs > Tully lab
CSHL labs > Zhong lab
Depositing User: CSHL Librarian
Date: July 2004
Date Deposited: 03 Feb 2012 16:45
Last Modified: 11 Jan 2018 20:49
PMCID: PMC454384
Related URLs:

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving