Carmell, M. A., Hannon, G. J. (March 2004) RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol, 11 (3). pp. 214-8. ISSN 1545-9993 (Print)
DOI: 10.1038/nsmb729
Abstract
Our understanding of RNA interference has been enhanced by new data concerning RNase III molecules. The role of Dicer has previously been established in RNAi as the originator of 22-mers characteristic of silencing phenomena. Recently, a related RNAse III enzyme, Drosha, has surfaced as another component of the RNAi pathway. In addition to biochemistry, protein structures have proven to be helpful in deciphering the enzymology of RNase III molecules.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Gene Silencing MicroRNAs genetics metabolism Models Genetic RNA Interference RNA Small Interfering genetics metabolism Ribonuclease III metabolism physiology |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab |
| Depositing User: | CSHL Librarian |
| Date: | March 2004 |
| Date Deposited: | 14 Feb 2012 17:20 |
| Last Modified: | 02 Dec 2016 19:49 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22336 |
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