Wilbrecht, L., Holtmaat, A., Wright, N., Fox, K., Svoboda, K. (April 2010) Structural plasticity underlies experience-dependent functional plasticity of cortical circuits. J Neurosci, 30 (14). pp. 4927-4932. ISSN 1529-2401 (Electronic) 0270-6474 (Linking)
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Abstract
The stabilization of new spines in the barrel cortex is enhanced after whisker trimming, but its relationship to experience-dependent plasticity is unclear. Here we show that in wild-type mice, whisker potentiation and spine stabilization are most pronounced for layer 5 neurons at the border between spared and deprived barrel columns. In homozygote alphaCaMKII-T286A mice, which lack experience-dependent potentiation of responses to spared whiskers, there is no increase in new spine stabilization at the border between barrel columns after whisker trimming. Our data provide a causal link between new spine synapses and plasticity of adult cortical circuits and suggest that alphaCaMKII autophosphorylation plays a role in the stabilization but not formation of new spines.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: | |
| Communities: | CSHL labs > Svoboda lab |
| Depositing User: | CSHL Librarian |
| Date: | 7 April 2010 |
| Date Deposited: | 20 Oct 2011 13:32 |
| Last Modified: | 13 Mar 2018 15:40 |
| PMCID: | PMC2910869 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15584 |
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