Molecular Evolution of piRNA and Transposon Control Pathways in Drosophila

Malone, C. D., Hannon, G. J. (May 2010) Molecular Evolution of piRNA and Transposon Control Pathways in Drosophila. Cold Spring Harb Symp Quant Biol. pp. 225-234. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

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URL: http://www.ncbi.nlm.nih.gov/pubmed/20453205

DOI: 10.1101/sqb.2009.74.052

Abstract

The mere prevalence and potential mobilization of transposable elements in eukaryotic genomes present challenges at both the organismal and population levels. Not only is transposition able to alter gene function and chromosomal structure, but loss of control over even a single active element in the germline can create an evolutionary dead end. Despite the dangers of coexistence, transposons and their activity have been shown to drive the evolution of gene function, chromosomal organization, and even population dynamics (Kazazian 2004). This implies that organisms have adopted elaborate means to balance both the positive and detrimental consequences of transposon activity. In this chapter, we focus on the fruit fly to explore some of the molecular clues into the long- and short-term adaptation to transposon colonization and persistence within eukaryotic genomes.

Item Type:	Paper
Uncontrolled Keywords:	transposable elements germline
Subjects:	organism description > animal > insect > Drosophila bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > piRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons
CSHL Authors:	Hannon, Gregory J. Malone, Colin D.
Communities:	CSHL labs > Hannon lab School of Biological Sciences > Publications
Depositing User:	CSHL Librarian
Date:	7 May 2010
Date Deposited:	03 Oct 2011 19:56
Last Modified:	22 Sep 2014 19:25
PMCID:	PMC3181074
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/15472

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