Hüber, M. R., Spector, D. L. (April 2010) Chromatin dynamics. Annual Review of Biophysics, 39. pp. 471-489.
Abstract
The expression patterns of many protein-coding genes are orchestrated in response to exogenous stimuli, as well as cell-type-specific developmental programs. In recent years, researchers have shown that dynamic chromatin movements and interactions in the nucleus play a crucial role in gene regulation. In this review, we highlight our current understanding of the organization of chromatin in the interphase nucleus and the impact of chromatin dynamics on gene expression. We also discuss the current state of knowledge with regard to the localization of active and inactive genes within the three-dimensional nuclear space. Furthermore, we address recent findings that demonstrate the movements of chromosomal regions and genomic loci in association with changes in transcriptional activity. Finally, we discuss the role of intra-and interchromosomal interactions in the control of coregulated genes. Copyright © 2010 by Annual Reviews. All rights reserved.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Chromosome territory Gene expression Gene positioning Nuclear organization |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics |
| CSHL Authors: | |
| Communities: | CSHL labs > Spector lab |
| Depositing User: | CSHL Librarian |
| Date: | April 2010 |
| Date Deposited: | 03 Oct 2011 13:56 |
| Last Modified: | 26 Jan 2015 16:15 |
| PMCID: | PMC2894465 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15436 |
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