Dhawale, A. K., Hagiwara, A., Bhalla, U. S., Murthy, V. N., Albeanu, D. F. (October 2010) Non-redundant odor coding by sister mitral cells revealed by light addressable glomeruli in the mouse. Nature Neuroscience, 13. pp. 1404-12. ISSN 1097-6256
Abstract
Sensory inputs frequently converge on the brain in a spatially organized manner, often with overlapping inputs to multiple target neurons. Whether the responses of target neurons with common inputs become decorrelated depends on the contribution of local circuit interactions. We addressed this issue in the olfactory system using newly generated transgenic mice that express channelrhodopsin-2 in all of the olfactory sensory neurons. By selectively stimulating individual glomeruli with light, we identified mitral/tufted cells that receive common input (sister cells). Sister cells had highly correlated responses to odors, as measured by average spike rates, but their spike timing in relation to respiration was differentially altered. In contrast, non-sister cells correlated poorly on both of these measures. We suggest that sister mitral/tufted cells carry two different channels of information: average activity representing shared glomerular input and phase-specific information that refines odor representations and is substantially independent for sister cells.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal behavior organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organism description > animal behavior > odor recognition bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal |
| CSHL Authors: | |
| Communities: | CSHL labs > Albeanu lab |
| Depositing User: | CSHL Librarian |
| Date: | 17 October 2010 |
| Date Deposited: | 29 Sep 2011 20:01 |
| Last Modified: | 04 Dec 2014 16:39 |
| PMCID: | PMC3208311 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15400 |
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