Zaratiegui, B. M., Irvine, D. V., Martienssen, R. A. (February 2007) Noncoding RNAs and gene silencing. Cell, 128 (4). pp. 763-76. ISSN 0092-8674 (Print)
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Abstract
Noncoding RNA has long been proposed to control gene expression via sequence-specific interactions with regulatory regions. Here, we review the role of noncoding RNA in heterochromatic silencing and in the silencing of transposable elements (TEs), unpaired DNA in meiosis, and developmentally excised DNA. The role of cotranscriptional processing by RNA interference and by other mechanisms is discussed, as well as parallels with RNA silencing in imprinting, paramutation, polycomb silencing, and X inactivation. Interactions with regulatory sequences may well occur, but at the RNA rather than at the DNA level.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals DNA Transposable Elements/genetics Epigenesis, Genetic/ genetics Gene Expression Regulation/ genetics Gene Silencing/ physiology Humans RNA Interference/physiology RNA, Untranslated/ genetics Repressor Proteins/genetics/metabolism X Chromosome Inactivation/genetics |
| Subjects: | bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi bioinformatics > genomics and proteomics > genetics & nucleic acid processing > epigenetics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > epigenetics organism description > animal > mammal > primates > hominids > human |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab |
| Depositing User: | CSHL Librarian |
| Date: | 23 February 2007 |
| Date Deposited: | 30 Aug 2011 18:52 |
| Last Modified: | 05 Jun 2013 15:23 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/15287 |
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