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Paper

Albrengues, J., Shields, M. A., Ng, D., Park, C. G., Ambrico, A., Poindexter, M. E., Upadhyay, P., Uyeminami, D. L., Pommier, A., Kuttner, V., Bruzas, E., Maiorino, L., Bautista, C., Carmona, E. M., Gimotty, P. A., Fearon, D. T., Chang, K., Lyons, S. K., Pinkerton, K. E., Trotman, L. C., Goldberg, M. S., Yeh, J. T., Egeblad, M. (September 2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science, 361 (6409). ISSN 0036-8075

Naguib, A., Mathew, G., Reczek, C. R., Watrud, K., Ambrico, A., Herzka, T., Salas, I. C., Lee, M. F., El-Amine, N., Zheng, W., Di Francesco, M. E., Marszalek, J. R., Pappin, D. J., Chandel, N. S., Trotman, L. C. (April 2018) Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. Cell Rep, 23 (1). pp. 58-67. ISSN 2211-1247 (Electronic)

Alexander, J., Kendall, J., McIndoo, J., Rodgers, L., Aboukhalil, R., Levy, D., Stepansky, A., Sun, G., Chobadjiev, L., Riggs, M., Cox, H., Hakker, I., Nowak, D. G., Laze, J., Llukani, E., Srivastava, A., Gruschow, S., Yadav, S. S., Robinson, B. D., Atwal, G., Trotman, L. C., Lepor, H., Hicks, J. B., Wigler, M., Krasnitz, A. (January 2018) Utility of single cell genomics in diagnostic evaluation of prostate cancer. Cancer Res, 78 (2). pp. 348-358. ISSN 0008-5472

Lee, M., Naguib, A., Trotman, L. C., El-Amine, N. (December 2017) Endocytosis and PTEN in Tumor Suppression. Molecular Biology of the Cell, 28 (26 ASC). Abstract M257. ISSN 1059-15241939-4586

Chen, M., Nowak, D. G., Narula, N., Robinson, B., Watrud, K., Ambrico, A., Herzka, T. M., Zeeman, M. E., Minderer, M., Zheng, W., Ebbesen, S. H., Plafker, K. S., Stahlhut, C., Wang, V. M., Wills, L., Nasar, A., Castillo-Martin, M., Cordon-Cardo, C., Wilkinson, J. E., Powers, S., Sordella, R., Altorki, N. K., Mittal, V., Stiles, B. M., Plafker, S. M., Trotman, L. C. (March 2017) The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol, 216 (3). pp. 641-656. ISSN 0021-9525

Senturk, S., Shirole, N. H., Nowak, D. G., Corbo, V., Pal, D., Vaughan, A., Tuveson, D. A., Trotman, L. C., Kinney, J. B., Sordella, R. (February 2017) Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization. Nat Commun, 8. p. 14370. ISSN 2041-1723 (Public Dataset)

Mathew, G., Hannan, A., Hertzler-Schaefer, K., Wang, F., Feng, G. S., Zhong, J., Zhao, J. J., Downward, J., Zhang, X. (November 2016) Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A, 113 (46). pp. 13156-13161. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

Labbe, D. P., Uetani, N., Vinette, V., Lessard, L., Aubry, I., Migon, E., Sirois, J., Haigh, J., Begin, L. R., Trotman, L. C., Paquet, M., Tremblay, M. L. (June 2016) PTP1B deficiency enables the ability of a high fat diet to drive the invasive character of PTEN-deficient prostate cancers. Cancer Res, 76 (11). pp. 3130-3135. ISSN 1538-7445 (Electronic)0008-5472 (Linking)

Nowak, D. G., Cho, H., Herzka, T., Wang, V. M. Y., Senturk, S., DeMarco, D. V., Ding, D., Fellmann, C., Beinortas, T., Kleinman, D., Watrud, K., Chen, M., Wilkinson, J. E., Castillo-Martin, M., Cordon-Cardo, C., Robinson, B. D., Trotman, L. C. (August 2015) Myc drives Pten/ p53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2. Cancer Research, 75 (Supple). Abstract 2258. ISSN 0008-5472

Stahlhut, C. E., Watrud, K. E., Ambrico, A. J., Cho, H., Wang, L. L., Qi, J., Cantley, L. C., Bradner, J., Trotman, L. C. (August 2015) Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer. Cancer Research, 75 (Supple). Abstract 2636. ISSN 0008-5472

Stahlhut, C., Slack, F. J. (July 2015) Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation. Cell Cycle, 14 (13). pp. 2171-80. ISSN 1551-4005 (Electronic)1551-4005 (Linking)

Trotman, L. C., Nowak, D. G., Cho, H., Herzka, T., Watrud, K., DeMarco, D. V., Wang, V. M., Senturk, S., Fellmann, C., Ding, D., Beinortas, T., Kleinman, D., Chen, M., Sordella, R., Wilkinson, J. E., Castillo-Martin, M., Cordon-Cardo, C., Robinson, B. D. (June 2015) Myc drives Pten/trp53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2. Cancer Discovery, 5 (6). pp. 636-651. ISSN 21598274

Cho, Hyejin, Herzka, Tali, Stahlhut, Carlos, Watrud, Kaitlin, Robinson, Brian D., Trotman, Lloyd C. (May 2015) Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome. Methods, 77-78. pp. 197-204. ISSN 1046-2023

Naguib, Adam, Bencze, Gyula, Cho, Hyejin, Zheng, Wu, Tocilj, Ante, Elkayam, Elad, Faehnle, Christopher R, Jaber, Nadia, Pratt, Christopher P, Chen, Muhan, Zong, Wei-Xing, Marks, Michael S, Joshua-Tor, Leemor, Pappin, Darryl J, Trotman, Lloyd C (April 2015) PTEN Functions by Recruitment to Cytoplasmic Vesicles. Molecular Cell, 58 (2). pp. 255-268. ISSN 1097-2765

Naguib, A., Bencze, G., Engle, D. D., Chio, II, Herzka, T., Watrud, K., Bencze, S., Tuveson, D. A., Pappin, D. J., Trotman, L. C. (December 2014) P53 Mutations Change Phosphatidylinositol Acyl Chain Composition. Cell Reports, 10 (1). pp. 8-19. ISSN 2211-1247

Reyes, G., Niederst, M., Cohen-Katsenelson, K., Stender, J. D., Kunkel, M. T., Chen, M., Brognard, J., Sierecki, E., Gao, T., Nowak, D. G., Trotman, L. C., Glass, C. K., Newton, A. C. (September 2014) Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proc Natl Acad Sci U S A, 111 (38). E3957-E3965. ISSN 0027-8424

Pulido, R., Baker, S. J., Barata, J. T., Carracedo, A., Cid, V. J., Chin-Sang, I. D., Dave, V., den Hertog, J., Devreotes, P., Eickholt, B. J., Eng, C., Furnari, F. B., Georgescu, M. M., Gericke, A., Hopkins, B., Jiang, X., Lee, S. R., Losche, M., Malaney, P., Matias-Guiu, X., Molina, M., Pandolfi, P. P., Parsons, R., Pinton, P., Rivas, C., Rocha, R. M., Rodriguez, M. S., Ross, A. H., Serrano, M., Stambolic, V., Stiles, B., Suzuki, A., Tan, S. S., Tonks, N. K., Trotman, L. C., Wolff, N., Woscholski, R., Wu, H., Leslie, N. R. (July 2014) A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science signaling, 7 (332). pe15. ISSN 1937-9145

Chen, M., Nowak, D. G., Trotman, L. C. (June 2014) Molecular Pathways: PI3K Pathway Phosphatases as Biomarkers for Cancer Prognosis and Therapy. Clinical Cancer Research, 20 (12). pp. 3057-63. ISSN 1078-0432

Cho, H., Herzka, T., Zheng, W., Qi, J., Wilkinson, J. E., Bradner, J. E., Robinson, B. D., Castillo-Martin, M., Cordon-Cardo, C., Trotman, L. C. (January 2014) RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer, reveals Myc as a driver of Pten-mutant metastasis. Cancer Discovery, 4 (3). pp. 318-33. ISSN 21598274

Labbé, D. P., Nowak, D. G., Deblois, G., Lessard, L., Giguère, V., Trotman, L. C., Tremblay, M. L. (2014) Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors. Molecular Cancer Research, 12 (2). pp. 184-189. ISSN 15417786 (ISSN)

Newton, A. C., Trotman, L. C. (2014) Turning off AKT: PHLPP as a drug target. Annu Rev Pharmacol Toxicol, 54. pp. 537-58. ISSN 1545-4304 (Electronic)0362-1642 (Linking)

Chen, M. H., Herzka, T. M., Zeeman, M. E., Plafker, K. S., Minderer, M., Castillo-Martin, M., Cordon-Cardo, C., Plafker, S. M., Trotman, L. C. (April 2013) PTEN levels are controlled by a nuclear transport receptor in lung cancer. Cancer Research, 73 (8 (Sup). p. 5258. ISSN 0008-5472

Cho, H. J., Herzka, T., Zheng, W., Castillo-Martin, M., Cordon-Cardo, C., Trotman, L. C. (April 2013) Rapid Cap: A new generation of mouse models for prostate cancer. Cancer Research, 73 (8 (Sup). p. 4091. ISSN 0008-5472

Naguib, A., Bencze, G., Faehnle, C. R., Schalch, T., Lazar, Z., Ruse, C. I., Joshua-Tor, L., Pappin, D. J., Trotman, L. C. (April 2013) Upstream activation of PTEN. Cancer Research, 73 (8 (Sup). p. 5156. ISSN 0008-5472

Naguib, A., Trotman, L. C. (2013) PTEN plasticity: how the taming of a lethal gene can go too far. Trends In Cell Biology, 23 (8). pp. 374-379. ISSN 0962-8924

Lessard, L., Labbé, D. P., Deblois, G., Beǵin, L. R., Hardy, S., Mes-Masson, A. M., Saad, F., Trotman, L. C., Giguére, V., Tremblay, M. L. (March 2012) PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Research, 72 (6). pp. 1529-1537. ISSN 00085472 (ISSN)

Xiong, Q., Oviedo, H. V., Trotman, L. C., Zador, A. M. (February 2012) PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex. Journal of Neuroscience, 32 (5). pp. 1643-52. ISSN 0270-6474

Howitt, J., Lackovic, J., Low, L. H., Naguib, A., Macintyre, A., Goh, C. P., Callaway, J. K., Hammond, V., Thomas, T., Dixon, M., Putz, U., Silke, J., Bartlett, P., Yang, B. L., Kumar, S., Trotman, L. C., Tan, S. S. (January 2012) Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia. Journal of Cell Biology, 196 (1). pp. 29-36. ISSN 0021-9525

Chen, M. H., Pratt, C. P., Zeeman, M. E., Schultz, N., Taylor, B. S., O'Neill, A., Castillo-Martin, M., Nowak, D. G., Naguib, A., Grace, D. M., Murn, J., Navin, N., Atwal, G. S., Sander, C., Gerald, W. L., Cordon-Cardo, C., Newton, A. C., Carver, B. S., Trotman, L. C. (August 2011) Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression. Cancer Cell, 20 (2). pp. 173-186. ISSN 1535-6108

Trotman, L. C. (March 2011) Calling on the cancer sleuths: how cell biologists will do the detective legwork of the postcancer genome era. Molecular Biology of the Cell, 22 (6). ISSN 10591524

Schreiber, S. L., Shamji, A. F., Clemons, P. A., Hon, C., Koehler, A. N., Munoz, B., Palmer, M., Stern, A. M., Wagner, B. K., Powers, S., Lowe, S. W., Guo, X., Krasnitz, A., Sawey, E. T., Sordella, R., Stein, L. D., Trotman, L. C., Califano, A., Dalla-Favera, R., Ferrando, A., Iavarone, A., Pasqualucci, L., Silva, J., Stockwell, B. R., Hahn, W. C., Chin, L., DePinho, R. A., Boehm, J. S., Gopal, S., Huang, A., Root, D. E., Weir, B. A., Gerhard, D. S., Zenklusen, J. C., Roth, M. G., White, M. A., Minna, J. D., MacMillan, J. B., Posner, B. A. (September 2010) Towards patient-based cancer therapeutics. Nature Biotechnology, 28 (9). pp. 904-906.

Trotman, L. C., Powers, S. (July 2010) New views into the prostate cancer genome. Cancer Cell, 18 (1). pp. 1-2. ISSN 1878-3686 (Electronic) 1535-6108 (Linking)

Alimonti, A., Carracedo, A., Clohessy, J. G., Trotman, L. C., Nardella, C., Egia, A., Salmena, L., Sampieri, K., Haveman, W. J., Brogi, E., Richardson, A. L., Zhang, J., Pandolfi, P. P. (May 2010) Subtle variations in Pten dose determine cancer susceptibility. Nature Genetics, 42 (5). pp. 454-458. ISSN 10614036 (ISSN) (In Press)

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., Rosivatz, E., Woscholski, R., Cognetti, F., Scher, H. I., Pandolfi, P. P. (March 2010) A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. Journal of Clinical Investigation, 120 (3). pp. 681-693. ISSN 00219738 (ISSN)

Murn, J., Mlinaric-Rascan, I., Vaigot, P., Alibert, O., Frouin, V., Gidrol, X. (July 2009) A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering. BMC Genomics, 10. p. 323.

Murn, J., Alibert, O., Wu, N., Tendil, S., Gidrol, X. (December 2008) Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. J Exp Med, 205 (13). pp. 3091-103.

Janas, M. L., Hodson, D., Stamataki, Z., Hill, S., Welch, K., Gambardella, L., Trotman, L. C., Pandolfi, P. P., Vigorito, E., Turner, M. (January 2008) The Effect of Deleting p110{delta} on the Phenotype and Function of PTEN-Deficient B Cells. Journal of Immunology, 180 (2). pp. 739-46. ISSN 0022-1767

Trotman, L. C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., Pavletich, N. P., Carver, B. S., Cordon-Cardo, C., Erdjument-Bromage, H., Tempst, P., Chi, S. G., Kim, H. J., Misteli, T., Jiang, X., Pandolfi, P. P. (January 2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell, 128 (1). pp. 141-56.

Wang, X., Trotman, L. C., Koppie, T., Alimonti, A., Chen, Z., Gao, Z., Wang, J., Erdjument-Bromage, H., Tempst, P., Cordon-Cardo, C., Pandolfi, P. P., Jiang, X. (January 2007) NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN. Cell, 128 (1). pp. 129-139. ISSN 00928674 (ISSN)

Trotman, L. C., Alimonti, A., Scaglioni, P. P., Koutcher, J. A., Cordon-Cardo, C., Pandolfi, P. P. (May 2006) Identification of a tumour suppressor network opposing nuclear Akt function. Nature, 441 (7092). pp. 523-527. ISSN 00280836 (ISSN)

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H. K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., Cordon-Cardo, C., Pandolfi, P. P. (August 2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature, 436 (7051). pp. 725-30. ISSN 1476-4687 (Electronic)0028-0836 (Linking)

Strunze, S., Trotman, L. C., Boucke, K., Greber, U. F. (2005) Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export. Molecular Biology of the Cell, 16 (6). pp. 2999-3009. ISSN 10591524 (ISSN)

Steffan, J. S., Agrawal, N., Pallos, J., Rockabrand, E., Trotman, L. C., Slepko, N., Illes, K., Lukacsovich, T., Zhu, Y. Z., Cattaneo, E., Pandolfi, P. P., Thompson, L. M., Marsh, J. L. (April 2004) SUMO Modification of Huntingtin and Huntington's Disease Pathology. Science, 304 (5667). pp. 100-104. ISSN 00368075 (ISSN)

Trotman, L. C., Achermann, D. P., Keller, S., Straub, M., Greber, U. F. (June 2003) Non-classical export of a adenovirus structural protein. Traffic, 4 (6). pp. 390-402. ISSN 13989219 (ISSN)

Trotman, L. C., Pandolfi, P. P. (February 2003) PTEN and p53: who will get the upper hand? Cancer Cell, 3 (2). pp. 97-9. ISSN 1535-6108 (Print)1535-6108 (Linking)

Trotman, L. C., Niki, M., Dotan, Z. A., Koutcher, J. A., Di Cristofano, A., Xiao, A., Khoo, A. S., Roy-Burman, P., Greenberg, N. M., Van Dyke, T., Cordon-Cardo, C., Pandolfi, P. P. (2003) Pten dose dictates cancer progression in the prostate. PLoS Biology, 1 (3). ISSN 1545-7885 (Electronic)1544-9173 (Linking)

Trotman, L. C., Mosberger, N., Fornerod, M., Stidwill, R. P., Greber, U. F. (2001) Import of adenovirus DNA involves the nuclear pore complex receptor CAN/Nup214 and histone H1. Nature Cell Biology, 3 (12). pp. 1092-1100. ISSN 14657392 (ISSN)

Stadler, K., Liu, N., Trotman, L. C., Hiltpold, A., Caderas, G., Klauser, S., Hehlgans, T., Gutte, B. (1995) Design, synthesis, and characterization of HIV-1 enhancer-binding polypeptides derived from bacteriophage 434 repressor. International Journal of Peptide and Protein Research, 46 (3-4). pp. 333-340. ISSN 03678377 (ISSN)

Book Section

Trotman, L. C. (2010) PTEN. In: Handbook of Cell Signaling (Second Edition). Academic Press, San Diego, pp. 849-854. ISBN 978-0-12-374145-5

Video

Trotman, L. C. (November 2011) Talk from Lloyd Trotman at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

This list was generated on Wed Dec 19 10:48:48 2018 EST.
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