Zender, Lars Publications

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Zender, Lars

Number of items at this level: 28.

Paper

Moon, S. H., Huang, C. H., Houlihan, S. L., Regunath, K., Freed-Pastor, W. A., Morris, J. P. th, Tschaharganeh, D. F., Kastenhuber, E. R., Barsotti, A. M., Culp-Hill, R., Xue, W., Ho, Y. J., Baslan, T., Li, X., Mayle, A., de Stanchina, E., Zender, L., Tong, D. R., D'Alessandro, A., Lowe, S. W., Prives, C. (December 2018) p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell, 176 (3). pp. 564-580. ISSN 0092-8674

Li, J., Chanrion, M., Sawey, E., Wang, T., Chow, E., Tward, A., Su, Y., Xue, W., Lucito, R., Zender, L., Lowe, S. W., Bishop, J. M., Powers, S. (March 2015) Reciprocal Interaction of Wnt and RXR-alpha Pathways in Hepatocyte Development and Hepatocellular Carcinoma. PLoS One, 10 (3). e0118480. ISSN 1932-6203

Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., Huang, C. H., Lechel, A., Andersen, J. B., Capper, D., Zender, L., Longerich, T., Enikolopov, G., Lowe, S. W. (July 2014) p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell, 158 (3). pp. 579-92. ISSN 0092-8674

Xue, W., Kitzing, T., Roessler, S., Zuber, J., Krasnitz, A., Schultz, N., Revill, K., Weissmueller, S., Rappaport, A. R., Simon, J., Zhang, J., Luo, W. J., Hicks, J., Zender, L., Wang, X. W., Powers, S., Wigler, M., Lowe, S. W. (May 2012) A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America, 109 (21). pp. 8212-8217. ISSN 0027-8424

Sawey, E. T., Chanrion, M., Cai, C., Wu, G., Zhang, J., Zender, L., Zhao, A., Busuttil, R. W., Yee, H., Stein, L. D., French, D. M., Finn, Richard S, Lowe, S. W., Powers, S. (March 2011) Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 19 (3). pp. 347-358. ISSN 1535-6108

Liu, L. X., Lee, N. P. , Chan, V. W. , Xue, W., Zender, L., Zhang, C., Mao, M., Dai, H., Wang, X. L., Xu, M. Z. , Lee, T. K. , Ng, I. O. , Chen, Y., Kung, H.-f. , Lowe, S. W. , Poon, R. T. P. , Wang, J. H., Luk, J. M. (November 2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology, 50 (5). pp. 1453-1463. ISSN 1527-3350

Bric, A., Miething, C., Bialucha, C. U., Scuoppo, C., Zender, L., Krasnitz, A., Xuan, Z., Zuber, J., Wigler, M. H., Hicks, J. B., McCombie, W. R., Hemann, M. T., Hannon, G. J., Powers, S., Lowe, S. W. (October 2009) Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell, 16 (4). pp. 324-35. ISSN 1535-6108

Xu, M. Z., Yao, T. J., Lee, N. P. Y., Ng, I. O. L., Chan, Y. T., Zender, L., Lowe, S. W., Poon, R. T. P., Luk, J. M. (October 2009) Yes-Associated Protein Is an Independent Prognostic Marker in Hepatocellular Carcinoma. Cancer, 115 (19). pp. 4576-4585. ISSN 0008-543X

Laska, M. J., Lowe, S. W., Zender, L., Hearn, S. A., Vogel, U., Jensen, U. B., Bric, A., Nexo, B. A. (September 2009) Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. Mol Carcinog, 48 (9). pp. 832-42.

Ma, O., Cai, W. W., Zender, L., Dayaram, T., Shen, J. H., Herron, A. J., Lowe, S. W., Man, T. K., Lau, C. C., Donehower, L. A. (March 2009) MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), Amplified on Chromosome 9, Collaborate with p53 Deficiency in Mouse Osteosarcoma Progression. Cancer Res, 69 (6). pp. 2559-2567. ISSN 0008-5472

Zender, L., Xue, W., Zuber, J., Semighini, C. P., Krasnitz, A., Ma, B., Zender, P., Kubicka, S., Luk, J. M., Schirmacher, P., McCombie, W. R., Wigler, M. H., Hicks, J. B., Hannon, G. J., Powers, S., Lowe, S. W. (November 2008) An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer. Cell, 135 (5). pp. 852-864. ISSN 0092-8674

Gyrd-Hansen, M., Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C., Zvelebil, M., Bujnicki, J. M., Lowe, S. W., Silke, J., Meier, P. (November 2008) IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol, 10 (11). pp. 1309-17.

Krizhanovsky, V., Yon, M., Dickens, R. A., Hearn, S. A., Simon, J., Ma, B., Miething, C., Zender, L., Lowe, S. W. (August 2008) Senescence of activated stellate cells limits liver fibrosis. Cell, 134 (4). 657-667 .

Burgess, D. J., Doles, J., Zender, L., Xue, W., Ma, B., McCombie, W. R., Hannon, G. J., Lowe, S. W., Hemann, M. T. (July 2008) Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A, 105 (25). pp. 9053-9058.

Xue, W., Krasnitz, A., Lucito, R., Sordella, R., Van Aelst, L., Cordon-Cardo, C., Singer, S., Kuehnel, F., Wigler, M. H., Powers, S., Zender, L., Lowe, S. W. (June 2008) DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development, 22 (11). pp. 1439-44. ISSN 0890-9369

Zender, L., Lowe, S. W. (January 2008) Integrative oncogenomic approaches for accelerated cancer-gene discovery. Curr Opin Oncol, 20 (1). pp. 72-6.

Krizhanovsky, V., Xue, W., Zender, L., Yon, M., Hernando, E., Lowe, S. W. (2008) Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol, 73. pp. 513-22.

Dickins, R. A., McJunkin, K., Hernando, E., Premsrirut, P. K., Krizhanovsky, V., Burgess, D. J., Kim, S. Y., Cordon-Cardo, C., Zender, L., Hannon, G. J., Lowe, S. W. (July 2007) Tissue-specific and reversible RNA interference in transgenic mice. Nat Genet, 39 (7). 914 - 921. ISSN 1061-4036 (Print)

He, L., He, X., Lim, L. P., De Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., Jackson, A. L., Linsley, P. S., Chen, C., Lowe, S. W., Cleary, M. A., Hannon, G. J. (June 2007) A microRNA component of the p53 tumour suppressor network. Nature, 447 (7148). pp. 1130-4. ISSN 1476-4687 (Electronic)

Zender, L., Zuber, J., Lowe, S. W. (May 2007) SnapShot: Genetic mouse models of cancer. Cell, 129 (4). p. 838. ISSN 0092-8674

Xue, W., Zender, L., Miething, C., Dickins, R. A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., Lowe, S. W. (February 2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature, 445 (7128). pp. 656-660. ISSN 0028-0836

Zender, L., Kubicka, S. (2007) Suppression of apoptosis in the liver by systemic and local delivery of small-interfering RNAs. Methods Mol Biol, 361. pp. 217-26. ISSN 1-59745-208-4

Zender, L., Xue, W., Cordon-Cardo, C., Lowe, S. W. (October 2006) P53 restoration in liver carcinomas induces cellular senescence and tumor clearance through an innate immune response. Hepatology, 44 (4). 694A-695A. ISSN 0270-9139

Wendel, H. G., Malina, A., Zhao, Z., Zender, L., Kogan, S. C., Cordon-Cardo, C., Pelletier, J., Lowe, S. W. (August 2006) Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Res, 66 (15). pp. 7639-46. ISSN 0008-5472 (Print)

Lakshmi, B., Hall, I. M., Egan, C., Alexander, J., Leotta, A., Healy, J., Zender, L., Spector, M. S., Xue, W., Lowe, S. W., Wigler, M. H., Lucito, R. (July 2006) Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proc Natl Acad Sci U S A, 103 (30). pp. 11234-9. ISSN 0027-8424 (Print)

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S. T., Luk, J. M., Wigler, M. H., Hannon, G. J., Mu, D., Lucito, R., Powers, S., Lowe, S. W. (June 2006) Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell, 125 (7). pp. 1253-67. ISSN 0092-8674 (Print)

Zender, L., Spector, M. S., Xue, W., Flemming, P., Mu, D., Cordon-Cardo, C., Powers, S., Hannon, G. J., Lucito, R., Lowe, S. W. (October 2005) Representational oligonucleotide microarray (ROMA) identifies cIAP1/cIAP2 as candidate oncogenes in mouse and human hepatocarcinogenesis-validation of cIAP1 as a therapeutic target in liver cancer in a new mouse model of hepatocellular carcinoma. Hepatology, 42 (4). 244A-244A. ISSN 0270-9139

Zender, L., Xue, W., Cordon-Cardo, C., Hannon, G. J., Lucito, R., Powers, S., Flemming, P., Spector, M. S., Lowe, S. W. (2005) Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors. Cold Spring Harb Symp Quant Biol, 70 (1). pp. 251-261. ISSN 1943-4456 (Electronic) 0091-7451 (Linking)

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