SR Splicing Factors Promote Cancer via Multiple Regulatory Mechanisms

Wan, Ledong, Deng, Min, Zhang, Honghe (September 2022) SR Splicing Factors Promote Cancer via Multiple Regulatory Mechanisms. Genes, 13 (9). p. 1659. ISSN 2073-4425

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Abstract

Substantial emerging evidence supports that dysregulated RNA metabolism is associated with tumor initiation and development. Serine/Arginine-Rich proteins (SR) are a number of ultraconserved and structurally related proteins that contain a characteristic RS domain rich in arginine and serine residues. SR proteins perform a critical role in spliceosome assembling and conformational transformation, contributing to precise alternative RNA splicing. Moreover, SR proteins have been reported to participate in multiple other RNA-processing-related mechanisms than RNA splicing, such as genome stability, RNA export, and translation. The dysregulation of SR proteins has been reported to contribute to tumorigenesis through multiple mechanisms. Here we reviewed the different biological roles of SR proteins and strategies for functional rectification of SR proteins that may serve as potential therapeutic approaches for cancer.

Item Type:	Paper
Subjects:	diseases & disorders > neoplasms bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > RNA binding protein bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > serine arginine rich proteins bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > splicing factor
CSHL Authors:	Wan, Ledong
Communities:	CSHL labs > Krainer lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	16 September 2022
Date Deposited:	27 Sep 2022 22:00
Last Modified:	27 Sep 2022 22:00
PMCID:	PMC9498594
URI:	https://repository.cshl.edu/id/eprint/40722

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