When the levee of sympathetic outflow breaks

Ferro, Austin, Cheadle, Lucas (August 2022) When the levee of sympathetic outflow breaks. Immunity, 55 (8). pp. 1334-1336. ISSN 1074-7613

Abstract

In this issue of Immunity, Bi et al. identify a microglia-neuron signaling axis that is critical for maintaining central control of the sympathetic nervous system. They find that platelet growth factor B released by microglia acts on neurons via PDGFRα to regulate sympathetic outflow. Disrupting this pathway leads to neuronal excitability, highlighting a promising therapeutic target to modulate sympathetic outflow and reduce hypertension.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons
organs, tissues, organelles, cell types and functions
CSHL Authors:
Communities: CSHL labs > Cheadle lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 9 August 2022
Date Deposited: 23 Aug 2022 22:04
Last Modified: 11 Jan 2024 20:00
URI: https://repository.cshl.edu/id/eprint/40701

Actions (login required)

Administrator's edit/view item Administrator's edit/view item