Ferro, Austin, Cheadle, Lucas (August 2022) When the levee of sympathetic outflow breaks. Immunity, 55 (8). pp. 1334-1336. ISSN 1074-7613
Abstract
In this issue of Immunity, Bi et al. identify a microglia-neuron signaling axis that is critical for maintaining central control of the sympathetic nervous system. They find that platelet growth factor B released by microglia acts on neurons via PDGFRα to regulate sympathetic outflow. Disrupting this pathway leads to neuronal excitability, highlighting a promising therapeutic target to modulate sympathetic outflow and reduce hypertension.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Cheadle lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 9 August 2022 |
| Date Deposited: | 23 Aug 2022 22:04 |
| Last Modified: | 11 Jan 2024 20:00 |
| URI: | https://repository.cshl.edu/id/eprint/40701 |
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