When the levee of sympathetic outflow breaks

Ferro, Austin, Cheadle, Lucas (August 2022) When the levee of sympathetic outflow breaks. Immunity, 55 (8). pp. 1334-1336. ISSN 1074-7613

URL: https://www.ncbi.nlm.nih.gov/pubmed/35947976

DOI: 10.1016/j.immuni.2022.07.009

Abstract

In this issue of Immunity, Bi et al. identify a microglia-neuron signaling axis that is critical for maintaining central control of the sympathetic nervous system. They find that platelet growth factor B released by microglia acts on neurons via PDGFRα to regulate sympathetic outflow. Disrupting this pathway leads to neuronal excitability, highlighting a promising therapeutic target to modulate sympathetic outflow and reduce hypertension.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions
CSHL Authors:	Ferro, Austin Cheadle, Lucas
Communities:	CSHL labs > Cheadle lab CSHL Post Doctoral Fellows
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	9 August 2022
Date Deposited:	23 Aug 2022 22:04
Last Modified:	16 Jan 2026 20:05
URI:	https://repository.cshl.edu/id/eprint/40701

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