Transcriptional regulation of primary and specialized metabolism

Brady, Siobhan (May 2022) Transcriptional regulation of primary and specialized metabolism. The FASEB Journal, 36 (S1). ISSN 0892-6638

DOI: 10.1096/fasebj.2022.36.s1.0i148

Abstract

Regulation of plant development requires intricate communication with both primary and specialized metabolism in order to fuel growth. While transcriptional regulation of metabolism is evident from myriad whole genome-expression analyses, our understanding of which transcriptional regulators are responsible for these changes as well as their underlying mode of action is unclear. I will highlight our efforts on systematic mapping of transcriptional regulators of primary metabolism (nitrogen and central carbon) as well as specialized metabolism (glucosinolates). Network analyses incorporating protein-DNA interaction data, gene expression and connectivity were used to identify critical regulators, most of which were shown to regulate metabolism via developmental- and stress-conditional processes that coordinate across primary and specialized metabolism. These analyses demonstrate distinct design principles responsible for metabolism between microbes and this multicellular eukaryote.

Item Type: Paper
CSHL Authors:
Communities: CSHL labs > Ware lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 13 May 2022
Date Deposited: 18 May 2022 14:04
Last Modified: 18 May 2022 14:04
URI: https://repository.cshl.edu/id/eprint/40612

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