Brady, Siobhan (May 2022) Transcriptional regulation of primary and specialized metabolism. The FASEB Journal, 36 (S1). ISSN 0892-6638
Abstract
Regulation of plant development requires intricate communication with both primary and specialized metabolism in order to fuel growth. While transcriptional regulation of metabolism is evident from myriad whole genome-expression analyses, our understanding of which transcriptional regulators are responsible for these changes as well as their underlying mode of action is unclear. I will highlight our efforts on systematic mapping of transcriptional regulators of primary metabolism (nitrogen and central carbon) as well as specialized metabolism (glucosinolates). Network analyses incorporating protein-DNA interaction data, gene expression and connectivity were used to identify critical regulators, most of which were shown to regulate metabolism via developmental- and stress-conditional processes that coordinate across primary and specialized metabolism. These analyses demonstrate distinct design principles responsible for metabolism between microbes and this multicellular eukaryote.
| Item Type: | Paper |
|---|---|
| CSHL Authors: | |
| Communities: | CSHL labs > Ware lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 13 May 2022 |
| Date Deposited: | 18 May 2022 14:04 |
| Last Modified: | 22 Nov 2023 19:18 |
| URI: | https://repository.cshl.edu/id/eprint/40612 |
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