Furlan, Alessandro, Corona, Alberto, Boyle, Sara, Sharma, Radhashree, Rubino, Rachel, Habel, Jill, Gablenz, Eva Carlotta, Giovanniello, Jacqueline, Beyaz, Semir, Janowitz, Tobias, Shea, Stephen D, Li, Bo (August 2021) Neurotensin neurons in the central extended amygdala control energy balance. bioRxiv. (Unpublished)
Abstract
Overeating and a sedentary life style are major causes of obesity and related metabolic disorders. Identification of the neurobiological processes that regulate energy balance will facilitate development of interventions for these disorders. Here we show that the Neurotensin-expressing neurons in the mouse IPAC (IPACNts), a nucleus of the central extended amygdala, bidirectionally coordinate hedonic feeding and physical activity, thereby regulating energy balance, metabolic processes and bodyweight. IPACNts are preferentially activated by consumption of highly palatable food or exposure to its taste and smell. Activating IPACNts promotes food intake in a palatability-dependent manner and decreases locomotion. Conversely, inhibiting IPACNts selectively reduces palatable food intake and dramatically enhances physical activity and energy expenditure, and in parallel stimulates physiological responses that oppose diet-induced obesity and metabolic dysfunctions. Thus, a single neuronal population, Neurotensin-expressing neurons in the IPAC, acts to control obesogenic and leptogenic processes by synergistically coordinating energy intake and expenditure with metabolism.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > amygdala bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > neurotensin diseases & disorders > nutritional and metabolic diseases > obesity |
| CSHL Authors: | |
| Communities: | CSHL labs > Beyaz lab CSHL labs > Janowitz lab CSHL labs > Li lab CSHL labs > Shea lab School of Biological Sciences > Publications |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 4 August 2021 |
| Date Deposited: | 28 Oct 2021 13:48 |
| Last Modified: | 29 Feb 2024 18:27 |
| URI: | https://repository.cshl.edu/id/eprint/40403 |
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