Neurotensin neurons in the central extended amygdala control energy balance

Furlan, Alessandro, Corona, Alberto, Boyle, Sara, Sharma, Radhashree, Rubino, Rachel, Habel, Jill, Gablenz, Eva Carlotta, Giovanniello, Jacqueline, Beyaz, Semir, Janowitz, Tobias, Shea, Stephen D, Li, Bo (August 2021) Neurotensin neurons in the central extended amygdala control energy balance. BioRxiv. (Unpublished)

URL: https://www.biorxiv.org/content/10.1101/2021.08.03...
DOI: 10.1101/2021.08.03.454970

Abstract

Overeating and a sedentary life style are major causes of obesity and related metabolic disorders. Identification of the neurobiological processes that regulate energy balance will facilitate development of interventions for these disorders. Here we show that the Neurotensin-expressing neurons in the mouse IPAC (IPACNts), a nucleus of the central extended amygdala, bidirectionally coordinate hedonic feeding and physical activity, thereby regulating energy balance, metabolic processes and bodyweight. IPACNts are preferentially activated by consumption of highly palatable food or exposure to its taste and smell. Activating IPACNts promotes food intake in a palatability-dependent manner and decreases locomotion. Conversely, inhibiting IPACNts selectively reduces palatable food intake and dramatically enhances physical activity and energy expenditure, and in parallel stimulates physiological responses that oppose diet-induced obesity and metabolic dysfunctions. Thus, a single neuronal population, Neurotensin-expressing neurons in the IPAC, acts to control obesogenic and leptogenic processes by synergistically coordinating energy intake and expenditure with metabolism.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > amygdala
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > neurotensin
diseases & disorders > nutritional and metabolic diseases > obesity
CSHL Authors:
Communities: CSHL labs > Beyaz lab
CSHL labs > Janowitz lab
CSHL labs > Li lab
CSHL labs > Shea lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 4 August 2021
Date Deposited: 28 Oct 2021 13:48
Last Modified: 28 Oct 2021 13:48
URI: https://repository.cshl.edu/id/eprint/40403

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