Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.

Dudok, Barna, Szoboszlay, Miklos, Paul, Anirban, Klein, Peter M, Liao, Zhenrui, Hwaun, Ernie, Szabo, Gergely G, Geiller, Tristan, Vancura, Bert, Wang, Bor-Shuen, McKenzie, Sam, Homidan, Jesslyn, Klaver, Lianne MF, English, Daniel F, Huang, Z Josh, Buzsáki, György, Losonczy, Attila, Soltesz, Ivan (October 2021) Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior. Neuron. ISSN 0896-6273

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Abstract

The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier" or axo-axonic cells (AACs). Although AACs are the only cellular source of GABA targeting the initial segment, their in vivo activity patterns and influence over pyramidal cell dynamics are not well understood. We achieved cell-type-specific genetic access to AACs in mice and show that AACs in the hippocampal area CA1 are synchronously activated by episodes of locomotion or whisking during rest. Bidirectional intervention experiments in head-restrained mice performing a random foraging task revealed that AACs inhibit CA1 pyramidal cells, indicating that the effect of GABA on the initial segments in the hippocampus is inhibitory in vivo. Finally, optogenetic inhibition of AACs at specific track locations induced remapping of pyramidal cell place fields. These results demonstrate brain-state-specific dynamics of a critical inhibitory controller of cortical circuits.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > tissues types and functions > axon organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Paul, Anirban Wang, Bor-Shuen Huang, Z. Josh
Communities:	CSHL labs > Huang lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	5 October 2021
Date Deposited:	20 Oct 2021 13:28
Last Modified:	23 Jan 2024 19:53
PMCID:	PMC8639676
URI:	https://repository.cshl.edu/id/eprint/40389

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