From human to mouse and back offers hope for patients with fibromyalgia

Tracey, KJ (July 2021) From human to mouse and back offers hope for patients with fibromyalgia. Journal of Clinical Investigation, 131 (13). ISSN 0021-9738

DOI: 10.1172/JCI150382


Fibromyalgia syndrome (FMS) is a highly prevalent, debilitating disease with heterogeneous symptoms of widespread pain and tenderness, fatigue, sleep disturbance, and impaired cognition. The cause of FMS is unknown, but the clinical constellation of symptoms and abnormalities in the neuroendocrine system, autonomic nervous system, and sleep implicate the nervous system in its pathogenesis. In this issue of the JCI, Goebel, Krock, et al. identified antibodies from patients with FMS that produce FMS in mice by binding to satellite glial cells (SGCs), which envelope sensory neurons. Because antibodies harvested from patients with FMS, but not controls, stimulated SGCs to an activated state known to mediate chronic pain by augmenting neuronal activity, these findings reveal a pivotal role for autoreactive IgG in the pathophysiology of FMS. These important findings pave a pathway to study mechanism-based experimental therapeutics targeting IgG titers or antibody binding to SGCs underlying the neuroimmune dysfunction of FMS.

Item Type: Paper
Subjects: diseases & disorders
diseases & disorders > immune system diseases
diseases & disorders > nervous system diseases and disorders
organism description > animal
organism description > animal > mammal
organism description > animal > mammal > rodent > mouse
Publication Type > review
organism description > animal > mammal > rodent
CSHL Authors:
Communities: CSHL labs > Tracey lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 1 July 2021
Date Deposited: 04 Aug 2021 17:54
Last Modified: 25 Jan 2024 19:39
PMCID: PMC8245165
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