MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

Chang, K. C., Diermeier, S. D., Yu, A. T., Brine, L. D., Russo, S., Bhatia, S., Alsudani, H., Kostroff, K., Bhuiya, T., Brogi, E., Bennett, C. F., Rigo, F., Spector, D. L. (February 2020) MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression. BioRxiv. (Unpublished)

DOI: 10.1101/2020.02.03.931881


Misregulation of long non-coding RNA genes has been linked to a wide variety of cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that plays a role in mammary tumor cell proliferation, migration, and invasion, both in vitro and in vivo. MaTAR25 functions by interacting with purine rich element binding protein B (PURB), and associating with a major downstream target gene Tensin 1 (Tns1) to regulate its expression in trans. Knockout of MaTAR25 results in down-regulation of Tns1 leading to a reorganization of the actin cytoskeleton, and a reduction of focal adhesions and microvilli. The human ortholog of MaTAR25, LINC01271, is upregulated with human breast cancer stage and metastasis.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > breast cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA
diseases & disorders > cancer > metastasis
CSHL Authors:
Communities: CSHL Cancer Center Program > Gene Regulation and Inheritance Program
CSHL labs > Spector lab
Depositing User: Sasha Luks-Morgan
Date: 3 February 2020
Date Deposited: 08 Jun 2021 15:54
Last Modified: 08 Jun 2021 15:54

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