Circadian immunity, sunrise time and the seasonality of respiratory infections.

Mo, Ziyi, Scheben, Armin, Steinberg, Joshua, Siepel, Adam, Martienssen, Robert (March 2021) Circadian immunity, sunrise time and the seasonality of respiratory infections. medRxiv. (Unpublished)

DOI: 10.1101/2021.03.29.21254556


The innate and adaptive immune response are regulated by biological clocks, and circulating lymphocytes are lowest at sunrise. Accordingly, severity of disease in mouse models is highly dependent on the time of day of viral infection. Here, we explore whether circadian immunity contributes significantly to seasonality of respiratory viruses, including influenza and SARS-CoV-2. Susceptibility-Infection-Recovery-Susceptibility (SIRS) models of influenza and SIRS-derived models of COVID-19 suggest that local sunrise time is a better predictor of the basic reproductive number ( R0 ) than climate, even when day length is taken into account. Moreover, these models predict a window of susceptibility when local sunrise time corresponds to the morning commute and contact rate is expected to be high. Counterfactual modeling suggests that retaining daylight savings time in the fall would reduce the length of this window, and substantially reduce seasonal waves of respiratory infections.

Item Type: Paper
Subjects: neurobiology > neuroscience > circadian rhythm
diseases & disorders > viral diseases > coronavirus > covid 19
diseases & disorders > viral diseases > influenza
CSHL Authors:
Communities: CSHL labs > Martienssen lab
CSHL labs > Siepel lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 31 March 2021
Date Deposited: 04 May 2021 15:43
Last Modified: 04 May 2021 15:43
PMCID: PMC8020986

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