Mineyeva, Olga A, Barykina, Natalia V, Bezriadnov, Dmitry V, Latushkin, Sergey T, Ryazanov, Alexander I, Unezhev, Vitaliy N, Shuvaev, Sergey A, Usova, Svetlana V, Lazutkin, Alexander A (May 2019) Suppressed neurogenesis without cognitive deficits: effects of fast neutron irradiation in mice. NeuroReport, 30 (8). pp. 538-543. ISSN 0959-4965
Abstract
This study assessed the effects of combined low-dose neutron and γ-ray irradiation on hippocampal neurogenesis and hippocampal-dependent memory. Neural progenitor cell division and survival were evaluated in brain sections and whole hippocampal preparations following head irradiation at a dose of 0.34 Gy for neutron radiation and 0.36 Gy for γ-ray radiation. Hippocampal-dependent memory formation was tested in a contextual fear conditioning task following irradiation at doses of 0.4 Gy for neutron radiation and 0.42 Gy for γ-ray radiation. Cell division was suppressed consistently along the entire dorsoventral axis of the hippocampus 24 h after the irradiation, but quiescent stem cells remained unaffected. The control and irradiated mice showed no differences in terms of exploratory behavior or anxiety 6 weeks after the irradiation. The ability to form hippocampus-dependent memory was also unaffected. The data may be indicative of a negligible effect of the low-dose of fast neutron irradiation and the neurogenesis suppression on animal behavior at 6 weeks after irradiation.
| Item Type: | Paper |
|---|---|
| Subjects: | |
| CSHL Authors: | |
| Communities: | CSHL labs > Koulakov lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 22 May 2019 |
| Date Deposited: | 03 Feb 2021 16:48 |
| Last Modified: | 03 Feb 2021 16:48 |
| URI: | https://repository.cshl.edu/id/eprint/39819 |
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