Suppressed neurogenesis without cognitive deficits: effects of fast neutron irradiation in mice.

Mineyeva, Olga A, Barykina, Natalia V, Bezriadnov, Dmitry V, Latushkin, Sergey T, Ryazanov, Alexander I, Unezhev, Vitaliy N, Shuvaev, Sergey A, Usova, Svetlana V, Lazutkin, Alexander A (May 2019) Suppressed neurogenesis without cognitive deficits: effects of fast neutron irradiation in mice. NeuroReport, 30 (8). pp. 538-543. ISSN 0959-4965

Abstract

This study assessed the effects of combined low-dose neutron and γ-ray irradiation on hippocampal neurogenesis and hippocampal-dependent memory. Neural progenitor cell division and survival were evaluated in brain sections and whole hippocampal preparations following head irradiation at a dose of 0.34 Gy for neutron radiation and 0.36 Gy for γ-ray radiation. Hippocampal-dependent memory formation was tested in a contextual fear conditioning task following irradiation at doses of 0.4 Gy for neutron radiation and 0.42 Gy for γ-ray radiation. Cell division was suppressed consistently along the entire dorsoventral axis of the hippocampus 24 h after the irradiation, but quiescent stem cells remained unaffected. The control and irradiated mice showed no differences in terms of exploratory behavior or anxiety 6 weeks after the irradiation. The ability to form hippocampus-dependent memory was also unaffected. The data may be indicative of a negligible effect of the low-dose of fast neutron irradiation and the neurogenesis suppression on animal behavior at 6 weeks after irradiation.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Shuvaev, Sergey
Communities:	CSHL labs > Koulakov lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	22 May 2019
Date Deposited:	03 Feb 2021 16:48
Last Modified:	02 Feb 2024 19:23
URI:	https://repository.cshl.edu/id/eprint/39819

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