Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism.

Lukey, M. J., Greene, K.S., Cerione, R.A. (March 2020) Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism. Mol Cell Oncol, 7 (3). p. 1735284. ISSN 2372-3556 (Electronic)2372-3556 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/32391426
DOI: 10.1080/23723556.2020.1735284

Abstract

The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD+-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.

Item Type: Paper
Subjects: diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > organs types and functions > metabolism
CSHL Authors:
Communities: CSHL labs > Lukey lab
Depositing User: Adrian Gomez
Date: 19 March 2020
Date Deposited: 18 May 2020 15:37
Last Modified: 14 Sep 2020 21:52
PMCID: PMC7199738
Related URLs:
URI: https://repository.cshl.edu/id/eprint/39464

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