Lukey, M. J., Greene, K.S., Cerione, R.A. (March 2020) Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism. Mol Cell Oncol, 7 (3). p. 1735284. ISSN 2372-3556 (Electronic)2372-3556 (Linking)
Abstract
The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD+-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > organs types and functions > metabolism organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions |
| CSHL Authors: | |
| Communities: | CSHL labs > Lukey lab |
| Depositing User: | Adrian Gomez |
| Date: | 19 March 2020 |
| Date Deposited: | 18 May 2020 15:37 |
| Last Modified: | 01 Feb 2024 16:04 |
| PMCID: | PMC7199738 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/39464 |
Actions (login required)
 |
Administrator's edit/view item |