Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes

Denton, A. E., Carr, E. J., Magiera, L. P., Watts, A. J. B., Fearon, D. T. (July 2019) Embryonic FAP(+) lymphoid tissue organizer cells generate the reticular network of adult lymph nodes. J Exp Med, 216 (10). pp. 2242-2252. ISSN 0022-1007

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Abstract

The induction of adaptive immunity is dependent on the structural organization of LNs, which is in turn governed by the stromal cells that underpin LN architecture. Using a novel fate-mapping mouse model, we trace the developmental origin of mesenchymal LN stromal cells (mLNSCs) to a previously undescribed embryonic fibroblast activation protein-alpha (FAP)(+) progenitor. FAP(+) cells of the LN anlagen express lymphotoxin beta receptor (LTbetaR) and vascular cell adhesion molecule (VCAM), but not intercellular adhesion molecule (ICAM), suggesting they are early mesenchymal lymphoid tissue organizer (mLTo) cells. Clonal labeling shows that FAP(+) progenitors locally differentiate into mLNSCs. This process is also coopted in nonlymphoid tissues in response to infection to facilitate the development of tertiary lymphoid structures, thereby mimicking the process of LN ontogeny in response to infection.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > immunity organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell organs, tissues, organelles, cell types and functions > cell types and functions > cell types > progenitor cell
CSHL Authors:	Fearon, Douglas
Communities:	CSHL labs > Fearon lab CSHL Cancer Center Program > Cellular Communication in Cancer Program
Depositing User:	Matthew Dunn
Date:	19 July 2019
Date Deposited:	09 Aug 2019 15:24
Last Modified:	26 Oct 2020 16:03
PMCID:	PMC6780995
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/38219

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