Arun, G., Spector, D. L. (March 2019) MALAT1 Long Non-Coding RNA and Breast Cancer. RNA Biol, 16 (6). pp. 860-863. ISSN 1547-6286
Abstract
Non-coding RNAs are becoming major players in disease pathogenesis such as cancer. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched long non-coding RNA that is generally overexpressed in patient tumors and metastases. Overexpression of MALAT1 has been shown to be positively correlated with tumor progression and metastasis in a large number of tumor types including breast tumors. Surprisingly, a recent report by Kim et al shows a metastasis suppressive role for Malat1. Here, we discuss these results in the context of a large body of published literature that support a pro-tumorigenic role for MALAT1 in order to gain potential insights into the basis of these observed differences.
Item Type: | Paper |
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Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA diseases & disorders > cancer > metastasis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > non-coding RNA |
CSHL Authors: | |
Communities: | CSHL Cancer Center Program > Gene Regulation and Inheritance Program CSHL labs > Spector lab |
Depositing User: | Matthew Dunn |
Date: | 15 March 2019 |
Date Deposited: | 25 Mar 2019 18:58 |
Last Modified: | 30 Nov 2020 19:59 |
PMCID: | PMC6546402 |
Related URLs: | |
URI: | https://repository.cshl.edu/id/eprint/37757 |
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