MALAT1 Long Non-Coding RNA and Breast Cancer

Arun, G., Spector, D. L. (March 2019) MALAT1 Long Non-Coding RNA and Breast Cancer. RNA Biol, 16 (6). pp. 860-863. ISSN 1547-6286

Abstract

Non-coding RNAs are becoming major players in disease pathogenesis such as cancer. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a nuclear enriched long non-coding RNA that is generally overexpressed in patient tumors and metastases. Overexpression of MALAT1 has been shown to be positively correlated with tumor progression and metastasis in a large number of tumor types including breast tumors. Surprisingly, a recent report by Kim et al shows a metastasis suppressive role for Malat1. Here, we discuss these results in the context of a large body of published literature that support a pro-tumorigenic role for MALAT1 in order to gain potential insights into the basis of these observed differences.

Item Type:	Paper
Subjects:	diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > long non-coding RNA diseases & disorders > cancer > metastasis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > non-coding RNA
CSHL Authors:	Spector, David L. Arun, Gayatri
Communities:	CSHL Cancer Center Program > Gene Regulation and Inheritance Program CSHL labs > Spector lab
Depositing User:	Matthew Dunn
Date:	15 March 2019
Date Deposited:	25 Mar 2019 18:58
Last Modified:	30 Nov 2020 19:59
PMCID:	PMC6546402
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/37757

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