Pai, E. L., Vogt, D., Clemente-Perez, A., McKinsey, G. L., Cho, F. S., Hu, J. S., Wimer, M., Paul, A., Fazel Darbandi, S., Pla, R., Nowakowski, T. J., Goodrich, L. V., Paz, J. T., Rubenstein, J. L. R. (January 2019) Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function. Cell Rep, 26 (5). 1157-1173.e5. ISSN 2211-1247
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Abstract
Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV(+)) and somatostatin (SST(+)) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST(+) cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.
| Item Type: | Paper |
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| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Huang lab |
| Depositing User: | Matthew Dunn |
| Date: | 29 January 2019 |
| Date Deposited: | 04 Feb 2019 21:02 |
| Last Modified: | 29 Jun 2021 20:04 |
| PMCID: | PMC6602795 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/37681 |
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