Exploring new routes for neuroprotective drug development in traumatic brain injury

Janowitz, T., Menon, D. K. (April 2010) Exploring new routes for neuroprotective drug development in traumatic brain injury. Sci Transl Med, 2 (27). 27rv1. ISSN 1946-6234

URL: https://www.ncbi.nlm.nih.gov/pubmed/20393189
DOI: 10.1126/scitranslmed.3000330


Worldwide, traumatic brain injury (TBI) is a major cause of mortality and morbidity with a substantial predicted increase in incidence. Despite an obvious need, there are no pharmacological treatment options for TBI because translation of neuroprotection from preclinical studies to clinical practice has so far failed. Here, we identify potential causes for this failure. We suggest that the monitoring and investigation tools that are commonly used in patients with TBI may provide an experimental medicine route to facilitate a more rational approach to translational research. This suggestion is underpinned by existing research data on disease biology, drug delivery, and treatment response obtained with these methods.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > organs types and functions > brain
CSHL Authors:
Communities: CSHL labs > Janowitz lab
Highlight: Janowitz, Tobias
Depositing User: Matthew Dunn
Date: 14 April 2010
Date Deposited: 10 Oct 2018 18:32
Last Modified: 10 Oct 2018 18:32
Related URLs:
URI: https://repository.cshl.edu/id/eprint/37230

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