Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth

Bružas, Emilis, Egeblad, Mikala (March 2018) Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth. Trends in Molecular Medicine, 24 (3). pp. 237-239. ISSN 1471-4914

DOI: 10.1016/j.molmed.2018.01.007


Cancer cells can directly stimulate the generation and recruitment of tumor-supportive bone marrow-derived cells (BMDCs), including neutrophils, via secreted factors. A new study demonstrates that lung tumors also remotely activate bone-residing osteoblasts, which in turn promote neutrophil production. This is a multistep mechanism of establishing a supportive tumor microenvironment.

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > lung cancer
CSHL Authors:
Communities: CSHL labs > Egeblad lab
School of Biological Sciences > Publications
Depositing User: Matt Covey
Date: March 2018
Date Deposited: 26 Mar 2018 16:48
Last Modified: 26 Mar 2018 16:48
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