Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth

Bružas, Emilis, Egeblad, Mikala (March 2018) Bone Talk: Activated Osteoblasts Promote Lung Cancer Growth. Trends in Molecular Medicine, 24 (3). pp. 237-239. ISSN 1471-4914

URL: https://www.ncbi.nlm.nih.gov/pubmed/29402707

DOI: 10.1016/j.molmed.2018.01.007

Abstract

Cancer cells can directly stimulate the generation and recruitment of tumor-supportive bone marrow-derived cells (BMDCs), including neutrophils, via secreted factors. A new study demonstrates that lung tumors also remotely activate bone-residing osteoblasts, which in turn promote neutrophil production. This is a multistep mechanism of establishing a supportive tumor microenvironment.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > neoplasms organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions diseases & disorders > cancer > cancer types > lung cancer organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neutrophils organs, tissues, organelles, cell types and functions diseases & disorders > cancer > cancer types
CSHL Authors:	Egeblad, Mikala Bruzas, Emilis
Communities:	CSHL labs > Egeblad lab School of Biological Sciences > Publications
Depositing User:	Matt Covey
Date:	March 2018
Date Deposited:	26 Mar 2018 16:48
Last Modified:	07 Feb 2024 18:32
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/36331

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