Cyclin in Fission Yeast

Solomon, M., Booher, R., Kirschner, M., Beach, D. (September 1988) Cyclin in Fission Yeast. Cell, 54 (6). pp. 738-739. ISSN 0092-8674

DOI: 10.1016/S0092-8674(88)90933-6


Genetic studies of the fission yeast cell cycle have identified the cdc2 gene as a critical regulator of M phase (Nurse and Thuriaux, 1980). The gene encodes a protein kinase (Simanis and Nurse, 1986) that is homologous to the product of the CDC28 cell cycle "start" gene of budding yeast (Beach et al., 1982). More recently it has become apparent that all eukaryotes including man have a similar protein kinase (Draetta et al., 1987; Lee and Nurse, 1987). Recent evidence suggests that the Xenopus homolog of the cdc2 product is a component of maturation promoting factor (MPF; Dunphy et al., 1988; Gautier et al., 1988), an activity that is capable of driving interphase nuclei into a mitotic state both in vivo and in vitro and that oscillates during the mitotic cell cycle (Gerhart et al., 1984; Newport and Kirschner, 1984).

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Cyclins
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Beach lab
Depositing User: Gail Sherman
Date: 6 September 1988
Date Deposited: 18 Sep 2017 16:24
Last Modified: 18 Sep 2017 16:24
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