NMDA receptor antagonists disrupt the retinotectal topographic map

Cline, H. T., Constantine-Paton, M. (October 1989) NMDA receptor antagonists disrupt the retinotectal topographic map. Neuron, 3 (4). pp. 413-26. ISSN 0896-6273

URL: http://www.ncbi.nlm.nih.gov/pubmed/2577128
DOI: 10.1016/0896-6273(89)90201-8


We tested the effect of two NMDA receptor antagonists, APV or MK801 (with NMDA), and the receptor agonist NMDA on the maintenance of retinal topography in frogs. Topography was assayed by measuring the dispersion of retrogradely labeled ganglion cells following a local HRP injection into the tectum. In untreated tadpoles, labeled cells covered about 5% of the retinal area. In APV- or MK801/NMDA-treated tadpoles, labeled ganglion cells covered 17% and 10% of the retinal area, respectively. Neither treatment with L-APV nor with NMDA disrupts the fidelity of the retinotectal projection. Neither APV- nor NMDA-treated ganglion cell terminals differed from untreated terminals with respect to tangential area, branch number, or branch density. These data support a role for the NDMA receptor in visual system development.

Item Type: Paper
Uncontrolled Keywords: 2-Amino-5-phosphonovalerate/administration & dosage/*pharmacology Animals Anura Aspartic Acid/administration & dosage/*analogs & derivatives/pharmacology Dibenzocycloheptenes/administration & dosage/*pharmacology Dizocilpine Maleate N-Methylaspartate Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter/*physiology Retina/cytology/*physiology Retinal Ganglion Cells/ultrastructure Superior Colliculus/cytology/*physiology
Subjects: bioinformatics > genomics and proteomics > small molecules > NMDA receptor
organism description > animal behavior > visual
CSHL Authors:
Communities: CSHL labs
Depositing User: Gail Sherman
Date: October 1989
Date Deposited: 28 Jul 2017 17:34
Last Modified: 28 Jul 2017 17:34
Related URLs:
URI: https://repository.cshl.edu/id/eprint/34837

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving