The Lateral Habenula Circuitry: Reward Processing and Cognitive Control

Baker, P. M., Jhou, T., Li, B., Matsumoto, M., Mizumori, S. J., Stephenson-Jones, M., Vicentic, A. (November 2016) The Lateral Habenula Circuitry: Reward Processing and Cognitive Control. J Neurosci, 36 (45). pp. 11482-11488. ISSN 1529-2401 (Electronic)0270-6474 (Linking)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/27911751
DOI: 10.1523/jneurosci.2350-16.2016

Abstract

There has been a growing interest in understanding the role of the lateral habenula (LHb) in reward processing, affect regulation, and goal-directed behaviors. The LHb gets major inputs from the habenula-projecting globus pallidus and the mPFC, sending its efferents to the dopaminergic VTA and SNc, serotonergic dorsal raphe nuclei, and the GABAergic rostromedial tegmental nucleus. Recent studies have made advances in our understanding of the LHb circuit organization, yet the precise mechanisms of its involvement in complex behaviors are largely unknown. To begin to address this unresolved question, we present here emerging cross-species perspectives with a goal to provide a more refined understanding of the role of the LHb circuits in reward and cognition. We begin by highlighting recent findings from rodent experiments using optogenetics, electrophysiology, molecular, pharmacology, and tracing techniques that reveal diverse neural phenotypes in the LHb circuits that may underlie previously undescribed behavioral functions. We then discuss results from electrophysiological studies in macaques that suggest that the LHb cooperates with the anterior cingulate cortex to monitor action outcomes and signal behavioral adjustment. Finally, we provide an integrated summary of cross-species findings and discuss how further research on the connectivity, neural signaling, and physiology of the LHb circuits can deepen our understanding of the role of the LHb in normal and maladaptive behaviors associated with mental illnesses and drug abuse.

Item Type: Paper
Uncontrolled Keywords: anterior cingulate cortex cognition globus pallidus lateral habenula punishment reward rostromedial tegmental nucleus
Subjects: organism description > animal behavior
organism description > animal behavior > perception > cognition
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
CSHL Authors:
Communities: CSHL labs > Li lab
Depositing User: Matt Covey
Date: 9 November 2016
Date Deposited: 13 Feb 2017 21:04
Last Modified: 06 Nov 2017 20:40
PMCID: PMC5125215
Related URLs:
URI: https://repository.cshl.edu/id/eprint/34061

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