Transcriptional errors and the drift barrier

McCandlish, D. M., Plotkin, J. B. (March 2016) Transcriptional errors and the drift barrier. Proc Natl Acad Sci U S A, 113 (12). pp. 3136-8. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

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DOI: 10.1073/pnas.1601785113


Population genetics predicts that the balance between natural selection and genetic drift is determined by the population size. Species with large population sizes are predicted to have properties governed mainly by selective forces; whereas species with small population sizes should exhibit features governed by mutational processes alone. This “drift-barrier hypothesis” has been successful in explaining extensive variation in genome size, mutation rate, transposable element abundance, and other molecular features across diverse taxa (1⇓–3). However, in PNAS Traverse and Ochman (4) report a striking exception to this theory by showing that transcriptional error rates are nearly equal across several bacterial species with very different population sizes.

Item Type: Paper
Uncontrolled Keywords: *Genetic Drift Humans
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing
CSHL Authors:
Communities: CSHL labs > McCandlish lab
Depositing User: Matt Covey
Date: 22 March 2016
Date Deposited: 18 Jan 2017 20:52
Last Modified: 08 Nov 2017 20:04
PMCID: PMC4812742
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