Is a super-enhancer greater than the sum of its parts?

Dukler, N., Gulko, B., Huang, Y. F., Siepel, A. (December 2016) Is a super-enhancer greater than the sum of its parts? Nat Genet, 49 (1). pp. 2-3. ISSN 1546-1718 (Electronic)1061-4036 (Linking)

DOI: 10.1038/ng.3759


The recent back-to-back articles by Hay et al.1 and Shin et al.2 both addressed the important question of how the constituent enhancers of a so-called 'super-enhancer' combine to activate the expression of a target gene. Super-enhancers are collections of closely spaced genomic regions that exhibit hallmarks of enhancers, such as binding by the Mediator complex and acetylation of histone H3 at lysine 27 (H3K27ac)3, 4, 5. As the authors of these articles noted1, 2, there is continuing controversy over whether super-enhancers genuinely represent a new paradigm in transcriptional regulation or whether they may essentially just be clusters of conventional enhancers that together produce a strong transcriptional response6.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
CSHL Authors:
Communities: CSHL labs > Siepel lab
CSHL Cancer Center Program > Cancer Genetics and Genomics Program
Depositing User: Matt Covey
Date: 28 December 2016
Date Deposited: 04 Jan 2017 16:13
Last Modified: 03 Nov 2020 14:21
PMCID: PMC5379849
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