Palmerini, E., Staals, E. L., Maki, R. G., Pengo, S., Cioffi, A., Gambarotti, M., Picci, P., Daolio, P. A., Parafioriti, A., Morris, C., Antonescu, C. R., Gronchi, A., Casali, P. G., Donati, D. M., Ferrari, S., Stacchiotti, S. (January 2015) Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. Eur J Cancer, 51 (2). pp. 210-7. ISSN 1879-0852 (Electronic)0959-8049 (Linking)
Abstract
BACKGROUND: Tenosynovial giant cell tumour/pigmented villonodular synovitis (TGCT/PVNS) is a benign neoplasm of synovium and tendon sheath. We conducted a retrospective pooled analysis in three major referral centers. METHODS: Patients treated between 1998 and 2008 were examined. Only patients presenting with primary disease or first relapse were included. 5-year local failure free survival (5-year-LFFS) was analysed. RESULTS: 294 patients were included: 254 with new diagnosis and 40 in 1st local recurrence (171 F/123 M; median age: 36 years; tumour size 2 cm in 27% of patients, >2 to 5 cm in 41%, and >5 cm in 32%). A diffuse pattern was reported in 69%, localised in 31%. No metastases were documented. Local failure (LF) was reported in 28% of patients: 36% in diffuse pattern, 14% in localised (p = 0.002); median time to LF: 16 months. With a median follow-up of 4.4 years, 5-year-LFFS was 66%, with multiple (up to five) local recurrences in 40% of relapsed patients. Size <2 cm, macroscopically complete resection, female gender and new diagnosis were associated with a better local control. After multivariate analysis, a previous relapse was independently associated with local failure. CONCLUSIONS: This study underlines the propensity of TGCT/PVNS to multiple local recurrences. In absence of clinical factors, biological studies are needed to identify prognostic factors of local failure. After a first local recurrence, surgery does not seem to have a curative potential. In these high risk patients, studies addressing the role of target therapies are needed.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adolescent Adult Aged Disease-Free Survival Female Follow-Up Studies Giant Cell Tumors/*pathology/surgery Humans Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Outcome Assessment (Health Care)/methods/statistics & numerical data Prognosis Retrospective Studies Synovial Membrane/*pathology/surgery Synovitis, Pigmented Villonodular/*pathology/surgery Tendons/*pathology/surgery Time Factors Young Adult Pigmented villonodular synovitis Prognostic factors Tenosynovial giant cell tumour Treatment Tyrosine kinase inhibitors |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase |
| CSHL Authors: | |
| Communities: | CSHL labs > Maki lab |
| Depositing User: | Matt Covey |
| Date: | January 2015 |
| Date Deposited: | 20 Oct 2016 14:05 |
| Last Modified: | 20 Oct 2016 14:05 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/33769 |
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