Pigmentary changes in a patient treated with imatinib

Balagula, Y., Pulitzer, M. P., Maki, R. G., Myskowski, P. L. (September 2011) Pigmentary changes in a patient treated with imatinib. J Drugs Dermatol, 10 (9). pp. 1062-6. ISSN 1545-9616 (Print)1545-9616 (Linking)

URL: https://www.ncbi.nlm.nih.gov/pubmed/22052279


Imatinib mesylate (STI 571; Gleevec; Novartis Pharmaceuticals, Basel, Switzerland) is an orally available tyrosine kinase inhibitor that targets a constitutively activated BCR-ABL tyrosine kinase with additional inhibitory effects on platelet derived growth factor (PDGF) receptors alpha and beta, and KIT. It has revolutionized the treatment of adult and pediatric patients with Philadelphia chromosome positive chronic myelogenous leukemia (CML) and is also FDA-approved for KIT-positive advanced gastrointestinal tumor (GIST) and dermatofibrosarcoma protuberans. A wide spectrum of dermatologic toxicities has been associated with this agent, among which a maculopapular rash is the most common event. In addition, a variety of pigmentary abnormalities of the skin and mucosal surfaces have been reported. Hypopigmentation is a well-recognized adverse effect. In contrast, paradoxical hyperpigmentation has only rarely been documented. In this case report we describe imatinib-induced cutaneous hyperpigmentation and graying of hair occurring in the same patient with dermatofibrosarcoma protuberans treated with imatinib.

Item Type: Paper
Uncontrolled Keywords: Adult Antineoplastic Agents/*adverse effects/therapeutic use Benzamides Dermatofibrosarcoma/drug therapy Follow-Up Studies Hair Color/*drug effects Humans Hyperpigmentation/*chemically induced Imatinib Mesylate Male Piperazines/*adverse effects/therapeutic use Pyrimidines/*adverse effects/therapeutic use Skin Pigmentation/drug effects
Subjects: diseases & disorders > cancer
diseases & disorders > cancer > drugs and therapies
CSHL Authors:
Communities: CSHL labs > Maki lab
Depositing User: Matt Covey
Date: September 2011
Date Deposited: 21 Oct 2016 19:21
Last Modified: 21 Oct 2016 19:21
Related URLs:
URI: https://repository.cshl.edu/id/eprint/33716

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