Tjian, R. (1979) Protein-DNA interactions at the origin of simian virus 40 DNA replication. Cold Spring Harbor Symposia on Quantitative Biology, 43 (2). pp. 655-61.
Abstract
The processes involved in initiating DNA replication have recently been studied with great success. The major advances have largely come from in vitro studies of simple bacteriophage systems such as those described in this volume (Meyer et al.; Eisenberg et al.; Godson; Schaller). The replication of more complex phages such as λ and of the bacterial host itself have also been examined in some detail (Messer et al.; Hirota et al.; Wickner; Hobom et al.; Furth et al.; all this volume). However, our knowledge of how higher eukaryotic cells initiate and control replication lags far behind. This is due partly to the difficulties of studying complex genomes and partly to the lack of replication-defective mutants to guide us through the maze of enzymatic reactions, which must be associated with the process of replication.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication organism description > virus > SV40 |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | 1979 |
| Date Deposited: | 06 May 2016 20:07 |
| Last Modified: | 06 May 2016 20:07 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32713 |
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