Sturm, R. A., Cassady, J. L., Das, G., Romo, A., Evans, G. A.
(May 1993)
Chromosomal Structure and Expression of the Human Otf1 Locus Encoding the Oct-1 Protein.
Genomics, 16 (2).
pp. 333-341.
ISSN 0888-7543
Abstract
The genomic structure of the POU domain containing oct-1 gene (OTF1 locus) coding region has been determined using human DNA recombinant bacteriophage and a yeast artificial chromosome clone. The gene is encoded by 16 exons spanning over 150 kb, and the Oct-1 protein reading frame has been extended to 766 amino acids. The exonic structure has been compared to the mouse Oct-2 protein and reveals a conservation of exon-intron boundaries as well as protein sequence similarity. To provide insight into Oct-1 control of transcriptional regulation during the cell-cycle the expression of the oct-1 gene was examined during cellular DNA replication and shows that the steady-state level of the oct-1 mRNA is not S-phase regulated.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
DNA-BINDING ACTIVITY
TRANSCRIPTION FACTOR
POU-DOMAIN
CELL-CYCLE
GENE
CONTAINS
VECTORS
CDNA
BOX
PHOSPHORYLATION |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > exons
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > histone |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Herr lab |
| Depositing User: |
Matt Covey
|
| Date: |
May 1993 |
| Date Deposited: |
19 Apr 2016 16:11 |
| Last Modified: |
19 Apr 2016 16:11 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/32519 |
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