Saccharomyces cerevisiae cell cycle: cdc28 and the G1 cyclins

Futcher, A. B. (August 1991) Saccharomyces cerevisiae cell cycle: cdc28 and the G1 cyclins. Semin Cell Biol, 2 (4). pp. 205-12. ISSN 1043-4682 (Print)1043-4682 (Linking)



Two families of cyclin-like proteins have been found in S. cerevisiae. The clb proteins are the mitotic cyclins. The cln proteins provide an essential function, are required for the G1/S transition, and appear to be rate-limiting for START, but have no obvious role elsewhere in the cycle. The cln proteins are unstable; they form complexes with cdc28; the complexes have protein kinase activity; and at least one of the clns oscillates in abundance through the cell cycle. The action of the cln cyclins at START suggests that they may be 'G1 cyclins'.

Item Type: Paper
Uncontrolled Keywords: CDC28 Protein Kinase, S cerevisiae/*physiology Cell Cycle/physiology Cyclins/*physiology G1 Phase/physiology Mitosis/physiology Saccharomyces cerevisiae/cytology/enzymology/*physiology
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > Cyclins
organism description > yeast > Saccharomyces
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Futcher lab
Depositing User: Matt Covey
Date: August 1991
Date Deposited: 21 Dec 2015 15:40
Last Modified: 21 Dec 2015 15:40

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