Conventions and nomenclature for double diffusion encoding NMR and MRI

Shemesh, N., Jespersen, S. N., Alexander, D. C., Cohen, Y., Drobnjak, I., Dyrby, T. B., Finsterbusch, J., Koch, M. A., Kuder, T., Laun, F., Lawrenz, M., Lundell, H., Mitra, P. P., Nilsson, M., Ozarslan, E., Topgaard, D., Westin, C. F. (January 2016) Conventions and nomenclature for double diffusion encoding NMR and MRI. Magn Reson Med, 75 (1). pp. 82-87. ISSN 1522-2594 (Electronic)0740-3194 (Linking)

DOI: 10.1002/mrm.25901


Stejskal and Tanner's ingenious pulsed field gradient design from 1965 has made diffusion NMR and MRI the mainstay of most studies seeking to resolve microstructural information in porous systems in general and biological systems in particular. Methods extending beyond Stejskal and Tanner's design, such as double diffusion encoding (DDE) NMR and MRI, may provide novel quantifiable metrics that are less easily inferred from conventional diffusion acquisitions. Despite the growing interest on the topic, the terminology for the pulse sequences, their parameters, and the metrics that can be derived from them remains inconsistent and disparate among groups active in DDE. Here, we present a consensus of those groups on terminology for DDE sequences and associated concepts. Furthermore, the regimes in which DDE metrics appear to provide microstructural information that cannot be achieved using more conventional counterparts (in a model-free fashion) are elucidated. We highlight in particular DDE's potential for determining microscopic diffusion anisotropy and microscopic fractional anisotropy, which offer metrics of microscopic features independent of orientation dispersion and thus provide information complementary to the standard, macroscopic, fractional anisotropy conventionally obtained by diffusion MR. Finally, we discuss future vistas and perspectives for DDE. Magn Reson Med, 2015. (c) 2015 Wiley Periodicals, Inc.

Item Type: Paper
Uncontrolled Keywords: diffusion diffusion mri double diffusion encoding double pfg double wave vector microstructure
Subjects: Investigative techniques and equipment > magnetic resonance imaging
CSHL Authors:
Communities: CSHL labs > Mitra lab
Depositing User: Matt Covey
Date: January 2016
Date Deposited: 01 Oct 2015 22:21
Last Modified: 02 Feb 2016 15:17
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